The Best Strains for a High THC Tolerance

If you’ve been consuming cannabis for a while, you might think that seeking out the highest THC strains is the key to achieving a more potent effect. However, this isn't always the best approach for those with high tolerance. Instead, consider giving your body a tolerance break from cannabis. A T-break can make an impact within a day or two; however, it takes about three weeks for THC to leave your body. Thus, a true T-break should be about 21 days long.

This downtime allows your CB1 receptors, which are critical for feeling the effects of cannabis, to regenerate. These receptors bind with cannabinoids like THC; a break can help restore their sensitivity. This means THC will feel more potent when you resume use. If taking a break isn't an option, then it’s time to stick to some of the strongest weed strains.

Godfather OG

For those with a high tolerance to cannabis strains, Godfather OG is a top-tier choice. Many call it the "Don of all OGs" as this indica-hybrid packs a potent kick thanks to its high THC levels, which typically reach up to 28%.

Godfather OG Feminized Seeds

The Godfather OG strain is an indica-dominant hybrid (60:40). It's gained a following for its impressive THC level, which averages 25%.

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While it's definitely not a strain for new smokers, it's a must-try for seasoned enthusiasts who are looking to get a more potent high.

As an indica-hybrid, a few tokes from Godfather OG will create a relaxing, euphoric effect. This makes it an ideal weed strain to enjoy after a long week or to help you fall asleep.

Godfather OG's unique terpene profile enhances its effectiveness. Myrcene and caryophyllene provide sedative qualities and pain relief. So, if you're on the lookout for a strain that can stand up to your high THC tolerance, Godfather OG is an easy choice.

Godfather OG cultivar profile

Do-si-dos

Do-si-dos is an excellent strain for those with high tolerance due to its flowers, which are rich in cannabinoids and have potent effects. With THC levels surpassing 25%, this indica-hybrid delivers an intense, long-lasting high that can satisfy even the most experienced smokers.

Do-si-dos Feminized Seeds

Do-si-dos is a newer strain, hitting the market around 2016. In a short time, though, the strain has built a large fanbase thanks to its high THC content, which can reach levels of 30%.

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With a parent strain like Girl Scout Cookies, it’s unsurprising that Do-si-dos can calm you down and make you feel on top of the world. Its distinct cookie-dough flavor might even make you crave actual cookies.

Do-si-dos (also in autoflower variant) are a great choice if you want something that delivers potency and taste and is excellent for someone who has a high tolerance to cannabis. For an even more intense experience, try this marijuana strain after taking a tolerance break. Laying off of cannabis for a few weeks helps your CB1 receptors regenerate, which are crucial to feeling its effects.

Do-si-dos cultivar profile

GMO Cookies

GMO Cookies is an indica-hybrid with THC levels ranging from 22% to 28%, making it one of the more potent weed strains for those with a high tolerance.

GMO Cookies Feminized Seeds

GMO Cookies, despite its unappealing name, is a potent indica-dominant hybrid with sativa-like growth but induces a strong indica couchlock. High THC levels make it suitable for experienced growers and users.

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For experienced smokers, it offers a powerful and long-lasting high. In addition to this strain’s strong kick, it is loved for its unique flavor profile that mixes diesel with garlic notes.

Besides the strain’s distinct taste and smell, GMO Cookies plants yield uniquely dense and resinous flowers that guarantee a rich, flavorful smoke once harvested. A hit of GMO Cookies starts with a euphoric rush that gradually melts into a calming body high. It makes for an excellent end-of-day strain after a hard day's work. Not only is GMO cookies available as a photoperiod strain, it also has an amazing autoflower version!

GMO Cookies cultivar profile

Amnesia Haze

Amnesia Haze is a classic strain that debuted in the early 90s, before the introduction of feminized seeds. It was considered one of the most potent sativa-hybrids in its decade.

Amnesia Haze Feminized Seeds

This feminized plant is a sativa-dominant strain with a high THC level of 21%. Amnesia Haze plants can be grown indoors or outdoors but typically thrive best in sunny climates.

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It was praised to the point of producing several elite clones and offspring that carry its mind-blowing effects and distinct flavor profile.

Take a T-break for a few weeks to get the most out of Amnesia Haze’s potent effects. A tolerance break intensifies this sativa hybrid's robust and heady buzz. Besides being perfect for normal grows, if you plan to grow autoflower plants, you are in luck, since this strain is also available as an autoflower!

Amnesia Haze cultivar profile

Fire OG

Similar to Godfather OG, Fire OG is one of the most potent OG strains and is enjoyed by many with a high THC tolerance. This strain boasts THC levels that typically surpass 20%, making its flowers powerful enough to meet the needs of most seasoned smokers.

Fire OG Feminized Seeds

Fire OG is a Cannabis strain with a sharp and distinct citrusy flavor. This hybrid's flavor is invigorating and makes your mouth water with anticipation of what's coming.

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If you’re familiar with Los Angeles, you'll know it's a hub for high-quality cannabis strains. This is thanks to the San Fernando Valley’s ideal climate and fertile cannabis-growing soil. SFV OG, a San Fernando Valley favorite, is a potent strain with soothing qualities that help with relaxation. It's also one of the parent strains that make up Fire OG after being crossed with OG Kush.

Like its parents, Fire OG is known for its strong sedative effects that can help with relaxation. The high leaves you euphoric, while the potent indica eases you into a peaceful sleep. This is especially true for cannabis users who've built up a tolerance to their usual sleep-boosting strain.

Fire OG cultivar profile

Gelato Sunrise

Developed by Phylos as part of their premium line of seeds, Gelato Sunrise is an excellent strain for users with high tolerance. It boasts THC levels that hover around 23%, so even seasoned smokers will feel the kick.

Gelato Sunrise Feminized Seeds

Gelato Sunrise, a standout in our Premium Feminized Sativa line, perfectly embodies the essence of indulgence with its delightful blend of sweet berry and cake-like flavors.

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Beyond producing a heady, energizing buzz, Gelato Sunrise delivers on flavor. If you love the taste of sweet berries and cake, you'll love the taste of Gelato Sunrise.

In addition to its potent effects and decadent flavors, this strain also has CBGA in its flowers. While that doesn't seem impressive at first since all cannabis plants contain CBGA in trace amounts, Gelato Sunrise flowers contain higher-than-average concentrations.

What makes CBGA so important? Recent studies showed that it possesses therapeutic properties similar to CBD, such as anti-anxiety, anti-inflammatory, and analgesic effects.

Typically, you'd only find around 1% CBGA in cannabis. With Phylos strains like Gelato Sunrise, flowers can contain up to 2.4% CBGA. This makes Gelato Sunrise more than a potent strain with an intense sativa high; it's also an excellent therapeutic strain for those looking to ease their pain or calm their nerves.

Gelato Sunrise cultivar profile

Berry Burst

Berry Burst is another premium sativa-hybrid developed by Phylos. This high THC strain boasts levels of around 26%. The uplifting strain delivers an energizing and uplifting buzz, making it a great wake-and-bake option.

Berry Burst Feminized Seeds

Berry Burst, a gem in our premium feminized Sativa collection, entices with its burst of sweet berry flavors reminiscent of a bowl of Fruity Pebbles or a glass of rose wine.

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It also contains around 2.3 CBGA, which is said to help stimulate appetite and provide various other therapeutic relief. This lets you enjoy Berry Burst's flavors, which combine sugary sweetness with the fresh taste of berries.

Berry Burst cultivar profile

Cheddar Cheeze

Cheddar Cheeze is a highly potent and flavorful indica-hybrid developed by Phylos. It is part of its elite line of seeds for home growers. It is excellent for those with high THC tolerance, as its flowers have an average THC level hovering around 30%.

Cheddar Cheeze Feminized Seeds

Cheddar Cheeze stands out with its unique combination of cheese, garlic, and mango aromas. The nose on this cultivar harkens back to the classic legacy aromas of UK Cheese.

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Because of its indica nature and high THC concentrations, Cheddar Cheeze provides a relaxing body high that promotes feelings of euphoria. Ideally, you would enjoy a strain as potent as Cheddar Cheeze when you have nothing to do but kick back and relax.

So, what does Cheddar Cheeze taste like? The name is a dead giveaway. Along with the taste and aroma of cheese, this indica-hybrid has notes of garlic and mangoes with each hit. Cheddar Cheeze is a must-try if you love a mix of savory and sweet flavors.

Cheddar Cheese cultivar profile

Lemon Fresh

Yet another one of Phylos’s elite line of seeds, Lemon Fresh is a potent sativa-hybrid made by crossbreeding Jungle Spice with Gorilla Diesel. The resulting strain’s flowers have THC levels of around 27%, making it a prime pick for people with high tolerance.

Lemon Fresh Feminized Seeds

Lemon Fresh, a distinguished feminized Sativa cultivar, brings a burst of gassy lemon flavor to the palette. Perfectly embodying the essence of its name, this strain is a power-packed combination of all that Sativas embodies.

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This sativa-hybrid has the flavor and aroma of gas and citrus. It isn’t just the high that gives Lemon Fresh its kick; its taste and smell are also dynamic. When you smoke Lemon Fresh flowers, you can expect the typical energizing buzz that sativas are known for.

Lemon Fresh cultivar profile

Super Yuzu

Super Yuzu is an artisanal combination of taste and potency. This hybrid strain has a THC level of around 21% and provides an intense yet calming high. It will make you feel relaxed and euphoric, like meditating in an orchard filled with yuzu trees.

Super Yuzu Feminized Seeds

Super Yuzu, an elite feminized Sativa from our exclusive collection, is a unique blend of tasty citrus flavors and functional effects. With its impressive THC content and vibrant terpene profile, it's an ideal choice for Sativa enthusiasts who want to enjoy an all-day smoke.

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In addition to its citrusy notes, Super Yuzu has a floral undertone that strongly resembles orange blossoms. With each toke, you can pick up notes of other citrus fruits, such as mandarin, grapefruit, and lemons.

The best way to enjoy any strain is to keep your THC tolerance in check. The occasional T-break gives every session the intensity you’re looking for. If you're unable to get your hands on the highest THC strain, you don’t have to necessarily hold off for four weeks. Our CB1 receptors regenerate quickly, with studies saying that by taking just a few days off, receptors will start to recover.

Super Yuzu cultivar profile

Sources used for this article

D’Souza, D. et al. (2016) Rapid Changes in Cannabinoid 1 Receptor Availability in Cannabis-Dependent Male Subjects After Abstinence From Cannabis [ScienceDirect]

Calapai, F. et al. (2022) Pharmacological Aspects and Biological Effects of Cannabigerol and Its Synthetic Derivatives [PubMed_Central]