The Best Strains for a High THC Tolerance

If you’ve been consuming cannabis for a while, you might think that seeking out the highest THC strains is the key to achieving a more potent effect. However, this isn't always the best approach for those with high tolerance. Instead, consider giving your body a tolerance break from cannabis. A T-break can make an impact within a day or two; however, it takes about three weeks for THC to leave your body. Thus, a true T-break should be about 21 days long.

This downtime allows your CB1 receptors, which are critical for feeling the effects of cannabis, to regenerate. These receptors bind with cannabinoids like THC; a break can help restore their sensitivity. This means THC will feel more potent when you resume use. If taking a break isn't an option, then it’s time to stick to some of the strongest weed strains.

For those with a high tolerance to cannabis strains, Godfather OG is a top-tier choice. Many call it the "Don of all OGs" as this indica-hybrid packs a potent kick thanks to its high THC levels, which typically reach up to 28%.

While it's definitely not a strain for new smokers, it's a must-try for seasoned enthusiasts who are looking to get a more potent high.

As an indica-hybrid, a few tokes from Godfather OG will create a relaxing, euphoric effect. This makes it an ideal weed strain to enjoy after a long week or to help you fall asleep.

Godfather OG's unique terpene profile enhances its effectiveness. Myrcene and caryophyllene provide sedative qualities and pain relief. So, if you're on the lookout for a strain that can stand up to your high THC tolerance, Godfather OG is an easy choice.

Do-si-dos is an excellent strain for those with high tolerance due to its flowers, which are rich in cannabinoids and have potent effects. With THC levels surpassing 25%, this indica-hybrid delivers an intense, long-lasting high that can satisfy even the most experienced smokers.

With a parent strain like Girl Scout Cookies, it’s unsurprising that Do-si-dos can calm you down and make you feel on top of the world. Its distinct cookie-dough flavor might even make you crave actual cookies.

Do-si-dos (also in autoflower variant) are a great choice if you want something that delivers potency and taste and is excellent for someone who has a high tolerance to cannabis. For an even more intense experience, try this marijuana strain after taking a tolerance break. Laying off of cannabis for a few weeks helps your CB1 receptors regenerate, which are crucial to feeling its effects.

GMO Cookies is an indica-hybrid with THC levels ranging from 22% to 28%, making it one of the more potent weed strains for those with a high tolerance.

For experienced smokers, it offers a powerful and long-lasting high. In addition to this strain’s strong kick, it is loved for its unique flavor profile that mixes diesel with garlic notes.

Besides the strain’s distinct taste and smell, GMO Cookies plants yield uniquely dense and resinous flowers that guarantee a rich, flavorful smoke once harvested. A hit of GMO Cookies starts with a euphoric rush that gradually melts into a calming body high. It makes for an excellent end-of-day strain after a hard day's work. Not only is GMO cookies available as a photoperiod strain, it also has an amazing autoflower version!

Amnesia Haze is a classic strain that debuted in the early 90s, before the introduction of feminized seeds. It was considered one of the most potent sativa-hybrids in its decade.

It was praised to the point of producing several elite clones and offspring that carry its mind-blowing effects and distinct flavor profile.

Take a T-break for a few weeks to get the most out of Amnesia Haze’s potent effects. A tolerance break intensifies this sativa hybrid's robust and heady buzz. Besides being perfect for normal grows, if you plan to grow autoflower plants, you are in luck, since this strain is also available as an autoflower!

Similar to Godfather OG, Fire OG is one of the most potent OG strains and is enjoyed by many with a high THC tolerance. This strain boasts THC levels that typically surpass 20%, making its flowers powerful enough to meet the needs of most seasoned smokers.

If you’re familiar with Los Angeles, you'll know it's a hub for high-quality cannabis strains. This is thanks to the San Fernando Valley’s ideal climate and fertile cannabis-growing soil. SFV OG, a San Fernando Valley favorite, is a potent strain with soothing qualities that help with relaxation. It's also one of the parent strains that make up Fire OG after being crossed with OG Kush.

Like its parents, Fire OG is known for its strong sedative effects that can help with relaxation. The high leaves you euphoric, while the potent indica eases you into a peaceful sleep. This is especially true for cannabis users who've built up a tolerance to their usual sleep-boosting strain.

Developed by Phylos as part of their premium line of seeds, Gelato Sunrise is an excellent strain for users with high tolerance. It boasts THC levels that hover around 23%, so even seasoned smokers will feel the kick.

Beyond producing a heady, energizing buzz, Gelato Sunrise delivers on flavor. If you love the taste of sweet berries and cake, you'll love the taste of Gelato Sunrise.

In addition to its potent effects and decadent flavors, this strain also has CBGA in its flowers. While that doesn't seem impressive at first since all cannabis plants contain CBGA in trace amounts, Gelato Sunrise flowers contain higher-than-average concentrations.

What makes CBGA so important? Recent studies showed that it possesses therapeutic properties similar to CBD, such as anti-anxiety, anti-inflammatory, and analgesic effects.

Typically, you'd only find around 1% CBGA in cannabis. With Phylos strains like Gelato Sunrise, flowers can contain up to 2.4% CBGA. This makes Gelato Sunrise more than a potent strain with an intense sativa high; it's also an excellent therapeutic strain for those looking to ease their pain or calm their nerves.

Berry Burst is another premium sativa-hybrid developed by Phylos. This high THC strain boasts levels of around 26%. The uplifting strain delivers an energizing and uplifting buzz, making it a great wake-and-bake option.

It also contains around 2.3 CBGA, which is said to help stimulate appetite and provide various other therapeutic relief. This lets you enjoy Berry Burst's flavors, which combine sugary sweetness with the fresh taste of berries.

Cheddar Cheeze is a highly potent and flavorful indica-hybrid developed by Phylos. It is part of its elite line of seeds for home growers. It is excellent for those with high THC tolerance, as its flowers have an average THC level hovering around 30%.

Because of its indica nature and high THC concentrations, Cheddar Cheeze provides a relaxing body high that promotes feelings of euphoria. Ideally, you would enjoy a strain as potent as Cheddar Cheeze when you have nothing to do but kick back and relax.

So, what does Cheddar Cheeze taste like? The name is a dead giveaway. Along with the taste and aroma of cheese, this indica-hybrid has notes of garlic and mangoes with each hit. Cheddar Cheeze is a must-try if you love a mix of savory and sweet flavors.

Yet another one of Phylos’s elite line of seeds, Lemon Fresh is a potent sativa-hybrid made by crossbreeding Jungle Spice with Gorilla Diesel. The resulting strain’s flowers have THC levels of around 27%, making it a prime pick for people with high tolerance.

This sativa-hybrid has the flavor and aroma of gas and citrus. It isn’t just the high that gives Lemon Fresh its kick; its taste and smell are also dynamic. When you smoke Lemon Fresh flowers, you can expect the typical energizing buzz that sativas are known for.